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Image Search Results
Journal: International Journal of Molecular Sciences
Article Title: HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation
doi: 10.3390/ijms21010122
Figure Lengend Snippet: Thrombopoietin (THPO) injection promotes hair growth in vivo, stimulating dermal papilla cells (DPCs). ( A ) Recombinant human THPO was injected into the dorsal skin of shaved mice. The hair weights were measured, skin sections were analyzed by HE staining, and numbers of mature hair follicles and hair follicles with Ki67 + cells were measured 16–17 days later. Asterisks indicate hair follicles with Ki67 + cells in the matrix amplifying zone. n = 4 per group. Three independent experiments were conducted. ( B ) THPO increased the length of mouse vibrissal hair follicles compared with the control. ( C ) THPO increased DPC proliferation dose- and time-dependently. ( D ) THPO upregulated the mRNA expression of DPC marker genes in DPC. * p < 0.05, ** p < 0.01, *** p < 0.001. Three independent experiments were conducted per data point. All error bars indicate the S.E.M.
Article Snippet: Human DPCs were purchased from PromoCell (#C-12071) and cultured in
Techniques: Injection, In Vivo, Recombinant, Staining, Expressing, Marker